Bacterial activity in cystic fibrosis lung infections

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Bacterial activity in cystic fibrosis lung infections

BACKGROUND Chronic lung infections are the primary cause of morbidity and mortality in Cystic Fibrosis (CF) patients. Recent molecular biological based studies have identified a surprisingly wide range of hitherto unreported bacterial species in the lungs of CF patients. The aim of this study was to determine whether the species present were active and, as such, worthy of further investigation ...

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Lung infections associated with cystic fibrosis.

While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is now recognized as a single disease whose diverse symptoms stem from the wide tissue distribution of the gene product that is defective in CF, the ion channel and regulator, cystic fibrosis transmembrane conductance regulator (CFTR). Defective CFTR protein impacts the function of the pancreas and alters ...

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Transmissible strains of Pseudomonas aeruginosa in cystic fibrosis lung infections.

Pseudomonas aeruginosa chronic lung infections are the major cause of morbidity and mortality associated with cystic fibrosis. For many years, the consensus was that cystic fibrosis patients acquire P. aeruginosa from the environment, and hence harbour their own individual clones. However, in the past 15 yrs the emergence of transmissible strains, in some cases associated with greater morbidity...

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Infections in patients with cystic fibrosis following lung transplantation.

BACKGROUND There is controversy over whether colonization with drug-resistant organisms is a contraindication to lung transplantation. METHODS We undertook a retrospective review of the results of lung transplantation for patients with cystic fibrosis (CF) at Duke University Medical Center. RESULTS As of May 1996, 21 patients with CF underwent bilateral lung transplantation. The first patie...

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Bacteriocin-mediated competition in cystic fibrosis lung infections.

Bacteriocins are toxins produced by bacteria to kill competitors of the same species. Theory and laboratory experiments suggest that bacteriocin production and immunity play a key role in the competitive dynamics of bacterial strains. The extent to which this is the case in natural populations,especially human pathogens, remains to be tested. We examined the role of bacteriocins in competition ...

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ژورنال

عنوان ژورنال: Respiratory Research

سال: 2005

ISSN: 1465-993X

DOI: 10.1186/1465-9921-6-49